OFF-ON-OFF Red-Emitting Fluorescent Indicators for a Narrow pH Window

Mitochondria-Immobilized pH-Sensitive Off–On Fluorescent Probe

We report here a mitochondria-targetable pH-sensitive probe that allows for a quantitative measurement of mitochondrial pH changes, as well as the real-time monitoring of pH-related physiological effects in live cells. This system consists of a piperazine-linked naphthalimide as a fluorescence off-on signaling unit, a cationic triphenylphosphonium group for mitochondrial targeting, and a reacti...

Review Study: Intravenous Thrombolysis, Time Window, Dosage, and Off-Label

Despite the development of Intravenous thrombolysis with tissue Plasminogen Activator (IVtPA) guidelines in each affiliated stroke center, protocol violations may be observed in each hospital with IVtPA facilities. An extensive search of scientific electronic databases including PubMed, OVID, Index Medicus, Index Copernicus, Google, ISI, and Scopus was performed with keywords of Thrombolysis, O...

A highly selective colorimetric and "off-on-off" fluorescent probe for fluoride ions.

In this paper, a highly selective and sensitive probe for fluoride ions (F(-)), containing a phenylpyridylvinylene derivative reporter and a Si-O bond receptor, was designed and characterized. The reaction mechanism is based on the intramolecular charge transfer (ICT) mechanism. Upon addition of F(-), probe 1 showed a remarkable red-shift (183 nm) in the absorption spectra accompanying with the...

Analytical Dynamic Modelling of Heel-off and Toe-off Motions for a 2D Humanoid Robot

The main objective of this article is to optimize the walking pattern of a 2D humanoid robot with heel-off and toe-off motions in order to minimize the energy consumption and maximize the stability margin. To this end, at first, a gait planning method is introduced based on the ankle and hip joint position trajectories. Then, using these trajectories and the inverse kinematics, the position tra...

pH-induced on/off-switchable graphene bioelectronics